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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   9

Issue No. :  4

Year :  2016

Pages :   423-429

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis, anti-larvicidal and anti-bacterial studies of 7-hydroxy-4- methylcoumarin, 7-acetoxy-4-methylcoumarin, 8-acetyl-7-hydroxy-4-methylcoumarin, resacetophenone, 8-acetyl-5-hydroxy-4-methylcoumarin and 4, 7-dimethylcoumarin



Address:   I. Prabha*, N.S. Nagarajan
Department of Chemistry, Sathyabama University, Jeppiar Nagar, Rajiv Gandhi Salai, Chennai-119
*Corresponding Author
DOI No: 10.5958/0974-360X.2016.00078.0

ABSTRACT:
The simple coumarins such as 7-hydroxy-4-methylcoumarin,7-acetoxy-4-methylcoumarin, 8-acetyl-7-hydroxy-4- methylcoumarin, resacetophenone, 8-acetyl-5-hydroxy-4-methylcoumarin and 4, 7-dimethylcoumarin were synthesized by Von Pechmann condensation reaction of ethyleacetoacetate with phenols. The effect of synthesized coumarins on their anti-larvicidal and anti-microbial activities was studied. Out of six synthesized coumarins 7-hydroxy-4-methylcoumarin was found to show significant effect and inhibited the growth of the organism Escherchia Coli and the II instar and IV instar larvae of culex quinquefasciatus.
KEYWORDS:
Coumarins, synthesis, larvicidal, microbial, organism.
Cite:
I. Prabha, N.S. Nagarajan. Synthesis, anti-larvicidal and anti-bacterial studies of 7-hydroxy-4- methylcoumarin, 7-acetoxy-4-methylcoumarin, 8-acetyl-7-hydroxy-4-methylcoumarin, resacetophenone, 8-acetyl-5-hydroxy-4-methylcoumarin and 4, 7-dimethylcoumarin.Research J. Pharm. and Tech. 2016; 9(4): 423-429.
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