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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   9

Issue No. :  4

Year :  2016

Pages :   340-344

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Developmental Toxicity of Arsenic and its Underlying Mechanisms in the early Embryonic Development



Address:   Bavanilathamuthiah1, Yoshitha Lakshmanan2, Purnima2, Ratnaprabha3
1 Associate Professor, Department of Biotechnology, Sathyabama University, Chennai
2Biotech, Sathyabama University, Chennai
4Department of Animal Biotechnology, Madras Veterinary College, Chennai- 7
*Corresponding Author
DOI No: 10.5958/0974-360X.2016.00060.3

ABSTRACT:
Arsenic is an environmental contaminant. Laboratory studies suggests negative effects of arsenic on early embryonic development in rodents, including decreased weight, affected fetal brain development and altered postnatal behavior. The Zebrafish serves as an important vertebrate model for studying development, genetics, and diseases. The present study uses wild-type zebra fish embryos to explore the potential developmental toxicity of arsenic and its underlying mechanisms in the early embryonic development. At the molecular level VEGF, PERP are been evaluated as they play a key role in angiogenesis and tumor development.
KEYWORDS:
Arsenic, Zebra Fish, toxicity, VEGF, PERP
Cite:
Bavanilathamuthiah, Yoshitha Lakshmanan, Purnima, Ratnaprabha. Developmental Toxicity of Arsenic and its Underlying Mechanisms in the early Embryonic Development. Research J. Pharm. and Tech. 9(4): April, 2016; Page 340-344.
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