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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   9

Issue No. :  3

Year :  2016

Pages :   227-234

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Prognostic Potential of Serum Biomarkers as Predictors for Cardiovascular Complications and Disease Progression in Chronic Kidney Disease Patients



Address:   Senthilkumar S*, Dhivya K
Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), VELS University, Pallavaram, Chennai – 600117.
*Corresponding Author
DOI No: 10.5958/0974-360X.2016.00041.X

ABSTRACT:
Aim: Chronic Kidney Disease (CKD) is characterized by progressive loss of kidney function over a period of time. The aim of the study is to determine the prognostic potential of serum biomarkers for cardiovascular complications and disease progression in chronic kidney disease patients. Materials and Methods: This retrospective observational study was carried out in the nephrology department of a multispecialty hospital for a period of two months. Clinical and biochemistry reports of 499 CKD patients were collected in designed case report forms. All statistical analysis was carried out using International Business Machine (IBM) Statistical Package for Social Sciences (SPSS) 17.0. Results: A direct correlation was observed between cardiac enzyme markers and phosphate levels. The product of Glycated Hemoglobin (HbA1c) and number of years of Diabetes Mellitus (DM) as predictive risk factors for development and progression of nephropathy (DN-CKD). Conclusion: This study has attempted to evaluate altered serum biomarkers as potential prognostic factors of cardiovascular complication and progressive renal impairment in CKD patients. Further prospective studies are required to gain deep insights into this and thereby aid in making significant clinical decisions.
KEYWORDS:
CKD, cardiomyocyte injury, biomarkers, hyperphosphatemia, diabetes
Cite:
Senthilkumar S, Dhivya K. Prognostic Potential of Serum Biomarkers as Predictors for Cardiovascular Complications and Disease Progression in Chronic Kidney Disease Patients. Research J. Pharm. and Tech. 2016; 9(3): 227-234.
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