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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   9

Issue No. :  3

Year :  2016

Pages :   215-218

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Weight and Content Uniformity of Warfarin Sodium Half Tablets



Address:   Mostafa Isbera1*, Ayat Abbood2, Wehad Ibrahim1 1Department of Pharmaceutics Faculty of Pharmacy , Tishreen University, Latakia, Syria 2Department of Quality Control , Faculty of Pharmacy , Tishreen University, Latakia, Syria *Corresponding Author
DOI No: 10.5958/0974-360X.2016.00039.1

ABSTRACT:
This study aims at investigating drug content and weight of the split half tablet using tablet splitter, hand, and knife for warfarin. Warfarin sodium tablets 5 mg (brand A, brand B, brand C, brand D ) were studied, and Weight variation and drug content were analyzed for warfarin sodium in 0.1N NaOH using spectrophotometer. The percentages of each whole tablets or half-tablet’s drug content and weight difference from sample mean values were compared with USP speci?cation ranges. All whole tablets and half tablets when tablet splitter was used meet the USP specification for weight and drug content ,while half tablets when hand and knife were used fail to meet the USP specification for weight and drug content. The % RSDs for drug content and weight meet the USP specification for whole warfarin sodium tablets and the half tablets which were split by tablet splitter, while halves which were split by hand and knife dont.
KEYWORDS:
Warfarin sodium, tablets, weight variation, drug content, half tablets, tablet splitter.
Cite:
Mostafa Isbera, Ayat Abbood, Wehad Ibrahim. Weight and Content Uniformity of Warfarin Sodium Half Tablets. Research J. Pharm. and Tech. 9(3): Mar., 2016; Page 215-218.
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