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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   9

Issue No. :  3

Year :  2016

Pages :   275-280

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Drug Interactions of H2 Receptor Antagonists- Ranitidine: A Review



Address:   Sarfaraz Ahmad1*, Md. Sajid Ali1, Nawazish Alam1, Md. Intakhab Alam1, Md. Sarfaraz Alam1, Md. Daud Ali2
1College of Pharmacy, Jazan University, Jazan, KSA.
2Department of Pharmacy, Mohammad Al-Mana College for Health Sciences, Al Khobar, KSA.
*Corresponding Author
DOI No: 10.5958/0974-360X.2016.00051.2

ABSTRACT:
Ranitidine has OTC drug status as well as it is an essential drug by WHO, hence it is popularly selling drug from community and hospital pharmacy. Many prescription and nonprescription drugs were found having drug interaction with ranitidine which may lead to either drug toxicity or therapy failure. This review compiles potential drug interactions of ranitidine with several categories of drugs along with effective measures. Ranitidine is in a group of drugs called histamine-2 blockers. H2 receptor antagonists continue to be prescribed usually for acid –peptic disease. Their safety record finally led to their availability as Over the Counter drugs. Histamine is a naturally-occurring chemical that stimulates cells in the stomach (parietal cells) to produce acid. H2-blockers inhibit the action of histamine on the cells, thus reducing the production of acid by the stomach. Ranitidine hydrochloride is prescribed for conditions such as gastroesophageal reflux disease (GERD), ulcers, Zollinger-Ellison syndrome, erosive esophagitis, upper gastrointestinal bleeding, heartburn, and other conditions where reduction of gastric secretion and acid output is desirable.
KEYWORDS:
Ranitidine, Drug interaction, H2 receptor antagonists, GERD, OTC.
Cite:
Sarfaraz Ahmad, Sajid Ali, Nawazish Alam, Intakhab Alam, Sarfaraz Alam, Daud Ali. Drug Interactions of H2 Receptor Antagonists- Ranitidine: A Review. Research J. Pharm. and Tech. 9(3): Mar., 2016; Page 275-280.
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