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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   9

Issue No. :  3

Year :  2016

Pages :   219-226

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and evaluation of extended release hard capsules of Furosemide



Address:   Zain Mhanna1*, Dr. Wehad Ibrahim2, Dr. Tamim Hammad3
1Master Student, Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Tishreen University, Syria. Syria-Lattakia
2Doctor in Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Tishreen University, Syria. Syria-Lattakia
3Assistant Professor in Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Tishreen University, Syria. Syria-Lattakia
*Corresponding Author
DOI No: 10.5958/0974-360X.2016.00040.8

ABSTRACT:
The aim of the present study is to prepare extended hard capsules of Furosemide using Eudragit RL, Eudragit RS and Ethyl cellulose individually in different ratios (6, 8, 12, and 15%) and different particle size of granules. The granules were prepared by wet granulation and then filled into capsules. The influence of different concentrations of polymer, type of polymer and granules size was studied. The prepared capsules assessed for their physicochemical properties and in-vitro drug release studies. The in vitro release data show that Ethyl cellulose has more retardation than Eudragits, and Eudragit RS retards drug release more than Eudragit RL does. In addition, higher concentration of polymer enhances the retardation better than lower concentration, and increasing the particle size of granules can alter the release of drug.
KEYWORDS:
Hard capsules, Furosemide, Wet granulation, Ethyl cellulose, Eudragit RS, Eudragit RL.
Cite:
Zain Mhanna, Wehad Ibrahim, Tamim Hammad. Formulation and evaluation of extended release hard capsules of Furosemide. Research J. Pharm. and Tech. 9(3): Mar., 2016; Page 219-226.
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