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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   9

Issue No. :  2

Year :  2016

Pages :   157-161

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Bioactivity of Hypomyces chrysospermus Methanol Extract



Address:   Pritha Chakraborty1, Vidhya Thangaraman2, Suji Thangamani2, Dhatchayani Ravi2, Jayanthi Abraham2*
1Research Associate,109 A Microbial Biotechnology Lab, School of Biosciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India.
2PG student,109 A Microbial Biotechnology Lab, School of Biosciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2016.00027.5

ABSTRACT:
Several attempts have been done to use different species of Hypomyces for the control of plant parasites. Though not much work has been done, this study was undertaken to explore antioxidant, antimicrobial and anticancer activity of Hypomyces chrysospermus through different screening tests. Antimicrobial activities were studied by agar well diffusion method against nine clinical pathogens. The total antioxidant capacity was evaluated by the DPPH assay and followed by cytotoxity activity on humam osteocarcoma (MG 63) cell line, using methanol extract as well as Thin Layer Chromatography (TLC) was performed for the separation of different components of the extract. Volatile extract of Hypomyces chrysospermus were also interpreted using Gas Chromatography and Mass spectrometry. Methanol extract of Hypomyces chrysospermus showed excellent antimicrobial activity against all tested pathogens. However only moderate antioxidant and anticancer activity was recorded.
KEYWORDS:
Hypomyces chrysospermus, Clinical pathogens, Osteocarcoma, Antimicrobial activity, Antioxidant activity.
Cite:
Pritha Chakraborty, Vidhya Thangaraman, Suji Thangamani, Dhatchayani Ravi, Jayanthi Abraham. Bioactivity of Hypomyces chrysospermus Methanol Extract. Research J. Pharm. and Tech. 9(2): Feb., 2016; Page 157-161.
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