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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   9

Issue No. :  12

Year :  2016

Pages :   2127-2134

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Transdermal Drug Delivery System of Ramipril

Address:   Dr. Chandrashekar C. Patil*, Bhavin Patel, Vitthal. K.Vijapure
Department of Pharmaceutics, B.L.D.A’s SSM College of Pharmacy, BLDE University Campus, Vijayapur – 586 103
Corresponding Author
DOI No: 10.5958/0974-360X.2016.00432.7

The purpose of this research work was to develop and evaluate matrix type transdermal patch of Ramipril, an ACE inhibitor and anti hypertensive drug using with Eudragit RL 100, Eudragit RS 100 and Ethyl cellulose in different ratios prepared by the Mercury Substrate Technique. The physicochemical compatibility of the polymers and the drug was evaluated by FTIR. The results suggested that no physicochemical incompatibility between the polymer and the drug. Drug free films were formulated and evaluated characteristics like flexible and smoothness. Further drug loaded films were formulated and evaluated for thickness, weight uniformity, drug content, water vapor transmission and skin irritation. The XRD analysis confirmed the amorphous dispersion of the drug. SEM analysis showed surface morphology of prepared formulations. Drug permeation through rat skin was carried out using Keshary-chein diffusion cells by in-vitro study. The film prepared with formulation RM-7 showed minimum permeation at the end of 24 hours. It is shown that drug release follows zero order and the mechanism of release is diffusion from the polymer. All the systems were found to be stable with respect to drug content as well as physical changes at 40 ºC and 75 % RH.
Transdermal drug delivery, Ramipril, Ethyl cellulose, Eudragit RS100, Eudragit RL 100
Chandrashekar C. Patil, Bhavin Patel, Vitthal. K.Vijapure. Formulation and Evaluation of Transdermal Drug Delivery System of Ramipril. Research J. Pharm. and Tech 2016; 9(12):2127-2134.
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