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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   9

Issue No. :  10

Year :  2016

Pages :   1641-1646

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Biomarker Genes for Gynaecological Cancers



Address:   Vimlendu Bhushan Sinha*, Neha Pandey, Pankaj Taneja
Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, Uttar Pradesh-201306, India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2016.00329.2

ABSTRACT:
Cancer is disease of uncontrolled cell proliferation. In the current set of investigation, data available on C-bioportal was used for enlist the biomarker genes in breast, ovarian and cervical cancers. A total of 29 biomarkers having potential for long term use in therapeutic developments were identified. Few prominent ones for breast cancer like BRCA1, ER, PR and Her2/neu, Ki67, PCNA in breast cancer prognosis, M-CSF, FSH and SMRP, CA-125, HE-4, mesothelin and GST, FOLRI and ALDH1, p53, Ki67, PCNA for monitoring ovarian cancer, HPV E6, E7, MCM, CDC6, P16INK4A and PCNA. Ki67 for tumor aggressiveness and metastatic potential of cervical cancer was identified. The current manuscript elucidates the importance and detection of gynecological cancer using biomarkers as a fast and reliable way for early disease detection.
KEYWORDS:
Cancer, Breast Cancer, Ovarian Cancer, Cervical Cancer, Biomarkers for Cancer
Cite:
Vimlendu Bhushan Sinha, Neha Pandey, Pankaj Taneja. Biomarker Genes for Gynaecological Cancers. Research J. Pharm. and Tech 2016; 9(10):1641-1646.
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