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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   9

Issue No. :  10

Year :  2016

Pages :   1615-1617

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Detection of blactx-m Gene for Esbl Resistance among Clinical Isolates of Klebsiella pneumoniae



Address:   Sara Banu1, Dr. Gopinath P2
1BDS 2 Year, Saveetha Dental College, Saveetha University, Chennai
2Senior Lecturer, Department of Microbiology, Saveetha University, Chennai
Corresponding Author
DOI No: 10.5958/0974-360X.2016.00320.6

ABSTRACT:
Abstract: Extended Spectrum Beta Lactamase (ESBL)-mediated antibiotic resistance is the rapidly growing mode of resistance observed in most of the clinically relevant Gram-negative pathogens. The organisms that produce CTX-M-beta lactamases are emerging now as resistance to oximinocephalosporin such as cefotaxime. Klebsiella species produce the enzyme ESBL and are resistant to many penicillin and cephalosporins. In our study we have used 20 clinical isolates of K. pneumoniae and were determined for their antibiotic susceptibility pattern followed by the detection of blaCTX-M gene by PCR. We have observed 15% of isolates were positive for this gene. We conclude that it is important to screen for other genes encoding ESBL for accurate and proper antibiotic management. This also emphasizes the need of following proper antibiotic rotational policies and judicial administration of drugs.
KEYWORDS:
Klebsiella pneumonia, blaCTX-M, PCR, ESBL
Cite:
Sara Banu, Gopinath P. Detection of blactx-m Gene for Esbl Resistance among Clinical Isolates of Klebsiella pneumoniae. Research J. Pharm. and Tech 2016; 9(10):1615-1617.
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