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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   9

Issue No. :  1

Year :  2016

Pages :   17-19

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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In Vitro Cytotoxicity Studies of Pamam Dendrimer with an Antifungal Agent



Address:   Jobin Jose*, R Narayana Charyulu, Prashant Nayak
Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Paneer, Mangalore-575018, Karnataka, India
*Corresponding Author
DOI No: DOI: 10.5958/0974-360X.2016.00004.4

ABSTRACT:
PAMAM dendrimer offers an ideal carrier for drug delivery that has the capacity to attach and discharge drugs by numerous ways. In this research work, we explored the potential of polyamidoamine dendrimers (PAMAM) as a carrier for ketoconazole and in vitro evaluation of ketoconazole- PAMAM complexes. Cytotoxicity studies were carried in J774A, mouse macrophage cell lines. Our research work revealed that binding of drug into dendrimers led to sustained release of ketoconazole in vitro. Results of the cytotoxicity studies also showed that the complexation of drugs with PAMAM dendrimer leads to the reduction in cytotoxicity of drugs.
KEYWORDS:
PAMAM Dendrimer, ketoconazole, drug dendrimer complexes, cytotoxicity.
Cite:
Jobin Jose, R Narayana Charyulu, Prashant Nayak. In Vitro Cytotoxicity Studies of Pamam Dendrimer with an Antifungal Agent. Research J. Pharm. and Tech. 9(1): Jan., 2016; Page 17-19.
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