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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   9

Issue No. :  1

Year :  2016

Pages :   11-16

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and In-Vitro Evaluation of Floating Tablet of Gabapentin

Address:   Nihar Ranjan Kar1*, Santosh Kumar Mahapatra2, Rajesh Kumar Pothal2, Chaitanya Pr. Meher1
1Department of Pharmaceutics, Gyan Vihar, Gayatri Institute of Science and Technology (GIST) Gunupur, Dist- Rayagada, 765022 Odisha.
2Dept. of Pharmaceutics, Gayatri College of Pharmacy, Sambalpur, Odisha.
*Corresponding Author
DOI No: 10.5958/0974-360X.2016.00003.2

The present research work is an attempt to formulate rate controlled drug delivery system of Gabapentin which is primarily absorbed from stomach, so by increasing the GRT of the drug, the bioavailability can be increased. As the drug is stable in acidic pH and mostly absorbed with in pH 1-3, as the stomach is the major absorption site for the drug. Basing on this fact the drug is made to float in the stomach using the mechanism of buoyancy. The study also includes various evaluation studies of Gabapentin tablet and the effect of processing variables on it. A possible interaction between drug and polymers are also investigated by FTIR and DSC studies. So, the present work has been under taken with the objective of designing and evaluation of floating oral sustained release tablet drug delivery system of Gabapentin by using HPMC K15, NaCMC, Xanthun gum, sodium bicarbonate, citric acid. Lactose, ethyl cellulose etc.
Gastric residence time (GRT), Gastric emptying time (GET), Sustained release, Drug release kinetics, Gabapentin.
Nihar Ranjan Kar, Santosh Kumar Mahapatra, Rajesh Kumar Pothal, Chaitanya Pr. Meher. Formulation and In-Vitro Evaluation of Floating Tablet of Gabapentin. Research J. Pharm. and Tech. 9(1): Jan., 2016; Page 11-16.
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