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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   8

Issue No. :  9

Year :  2015

Pages :   1250-1258

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Antimicrobial activity of newly Synthesized Pyrazolidine-3, 5-dione Substituted Thiochromene Derivatives



Address:   Ruchi Choubey1*, Neelesh Choubey2, Gopal Garg3
1Department of Pharmacy, Gyan-Vihar University, Jaipur (Rajasthan)
2School of Pharmacy, SSSUTMS, Sehore (M. P.)
3Department of Pharmaceutical Chemistry, Oriental College of Pharmacy, Bhopal (M.P.)
*Corresponding Author
DOI No: 10.5958/0974-360X.2015.00227.9

ABSTRACT:
A series of novel Synthesis of 1-(2-Methyl-4-oxo-4H-thiochromene-8-carbonyl)-2-arylpyrazolidine- 3,5-dione (20 - 35) were synthesized with different aromatic hydrazides and evaluated for Anti-inflammatory and Analgesic activity. The structures of the compounds were confirmed by TLC, FTIR, 1H NMR, 13C NMR and Mass spectral data. The antibacterial and antifungal activity was performed by Broth Dilution Method. The results of antibacterial activity of the thio-chromene derivatives showed better antibacterial activity against various bacterial strains. Their antimicrobial activities against P. vulgaris, B. subtilis, S. epidermidis, P. mirabilis, M. luteus, S. aureus, S. hominis, B. pumilus, S. typhi, K. pneumonia, E. coli, B. cereus, P. aeruginosa, A. niger, A. awamori, C. albicans, A. alternate, M. canis, T. longiformis, A. flavus, F. solani, T. viride were investigated.
KEYWORDS:
Antibacterial, Antifungal, Thiochromene, 3, 5-Pyrazolidine-dione.
Cite:
Ruchi Choubey, Neelesh Choubey, Gopal Garg. Antimicrobial activity of newly Synthesized Pyrazolidine-3, 5-dione Substituted Thiochromene Derivatives. Research J. Pharm. and Tech. 8(9): Sept, 2015; Page 1250-1258.
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