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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   8

Issue No. :  4

Year :  2015

Pages :   404-406

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Antifertility Effects of Rhizome of Curcuma longa on Seminal Parameters of Swiss Albino Male Mice



Address:   Anita Raj Hembrom*, Aarti Verma, V.N. Singh
University Department of Zoology, T.M. Bhagalpur University, Bhagalpur– 812007, Bihar, INDIA
*Corresponding Author
DOI No: 10.5958/0974-360X.2015.00068.2

ABSTRACT:
The effects of aqueous extract of rhizome of Curcuma longa on the seminal parameters of Swiss Albino male mice were investigated in this study. 36 mice were divided into six groups of six mice each with one group serving as control. Distilled water (0.1 ml) was administrated orally to control group while remaining five groups were fed with 0.1 ml (500 mg/kg BW/day) aqueous extract of rhizome of Curcuma longa for 10, 20, 30, 40 and 50 days. After completion of respective days, controls along with treated mice were sacrificed and semen from caudal epididymal part was assessed for seminal parameters such as sperm counts, motility of spermatozoa, seminal pH and mortality of the sperms. Sperm counts, sperm motility and seminal pH of cauda epididymis shows highly significant decline during 30 to 50 days treatment (p<0.001) than the control while mortality of spermatozoa increases significantly (p<0.001) than the control group of mice. Such significant alteration suggest that aqueous extract of rhizome of Curcuma longa produced adverse effects in seminal parameters and thus cause infertility among the treated groups of mice.
KEYWORDS:
Curcuma longa, seminal parameters, contraception.
Cite:
Anita Raj Hembrom, Aarti Verma, V.N. Singh. Antifertility Effects of Rhizome of Curcuma longa on Seminal Parameters of Swiss Albino Male Mice. Research J. Pharm. and Tech. 8(4): April, 2015; Page 404-406.
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