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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   8

Issue No. :  4

Year :  2015

Pages :   376-381

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Method Development and Validation for the Estimation of Telmisartan and Chlorthalidone in Bulk and Pharmaceutical Dosage form by HPTLC Method



Address:   Mrs. Aishwarya P. Joglekar
Shree Ambabai Talim Sanstha’s Diploma in Pharmacy College. Miraj, Maharashtra 416414
*Corresponding Author
DOI No: 10.5958/0974-360X.2015.00063.3

ABSTRACT:
In this study, the author has developed a HPTLC method for the estimation of Telmisartan and Chlorthalidone in commercial brand of ERITEL-CH40 mg containing 40 mg of Telmisartan and 12.5 mg of Chlorthalidone. The values obtained suggested that the proposed HPTLC method was simple, precise, rapid and robust for determination of Telmisartan and Chlorthalidone. The mobile phase was simple to prepare and economical. The authors then validated the method as per ICH guidelines and correlated the obtained values with standard values. Satisfactory results were obtained. The sample recoveries in all formulations were in good agreement with their respective label claims and they suggested noninterference of formulation excipients in the estimation. Hence, the method can be easily and conveniently adopted for routine estimation of Telmisartan and Chlorthalidone in tablet dosage form.
KEYWORDS:
Telmisartan, Chlorthalidone, method development, validation and HPTLC.
Cite:
Mrs. Aishwarya P. Joglekar. Method Development and Validation for the Estimation of Telmisartan and Chlorthalidone in Bulk and Pharmaceutical Dosage form by HPTLC Method. Research J. Pharm. and Tech. 8(4): April, 2015; Page 376-381.
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