2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   8

Issue No. :  3

Year :  2015

Pages :   276-279

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Synthesis and Antimicrobial Activity of Some New Chalcones Containing Benzofuran and Benzofuran Schiff Bases



Address:   Lunkad A.S.*, Kothawade S.N., Jadhav D.V., Chaudhari P.S., Bornare S.P.
SCSSS’s Sitabai Thite College of Pharmacy, Shirur (Ghodnadi), Dist-Pune.
*Corresponding Author
DOI No: 10.5958/0974-360X.2015.00046.3

ABSTRACT:
Benzofuran nucleus frequently occurs in natural products. In the present course of study an attempt is made for synthesis of new Benzofuran derivatives. 5-chloro-2-hydroxy acetophenone 2 was prepared by the Fries rearrangement with anhydrous aluminium chloride at 1300c for 3 hrs. The compound 2 was treated with chloroacetone in presence of anhydrous acetone and potassium carbonate gave 5-chloro-3-methyl-2-acetyl Benzofuran 3. Compound 3 underwent condensation with aromatic aldehyde and aromatic amines to furnished chalcone and Schiff derivatives 4a-e and 5a-e respectively. The synthesized compounds were screened for their antimicrobial activities.
KEYWORDS:
5-chloro-2-hydroxy acetophenone, Chalcone, Schiff base, Antimicrobial activity.
Cite:
Lunkad A.S., Kothawade S.N., Jadhav D.V., Chaudhari P.S., Bornare S.P. Synthesis and Antimicrobial Activity of Some New Chalcones Containing Benzofuran and Benzofuran Schiff Bases. Research J. Pharm. and Tech. 8(3): Mar., 2015; Page 276-279.
[View HTML]      [View PDF]



Visitor's No. :   657444