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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   8

Issue No. :  2

Year :  2015

Pages :   177-184

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Study of The Protective Effect of Vitamin C plus E on Lincomycin-Induced Hepatotoxicity and Nephrotoxicity.



Address:   Dr. Saher Mahmood Jwad1, Dr. Bushra Abbas2, Dr. Haider S. Jaffat3
1,2Biology Department, Faculty of Education for Girls, Kufa University, Iraq
3Biology Department, Faculty of Science, Kufa University, Iraq
*Corresponding Author
DOI No: 10.5958/0974-360X.2015.00032.3

ABSTRACT:
The objective of the present study was to compare the beneficial effects of vitamins C and E on Lincomycin-induced hepatotoxicity and nephrotoxicity. Sixteen of male albino rats sexually matured were randomly divided into four groups: (i) control, (ii) Lincomycin (500 mg/kg) administrated orally, (iii) Lincomycin plus vitamin C (500 mg/kg) and vitamin E (400 mg/kg), (iv) vitamin C plus vitamin E were administrated orally at the same doses of third group. Lincomycin treatments were started directly (1) day after the first administrations of these vitamins and continued for (21) days. At the end of the experiments: body weight, liver, kidney and spleen relative weights, erythrocytes sedimentation rate, urea, total bilirubin, creatinine, malondialdehyde, glutathione, total cholesterol, triglycerides, low density lipoproteins, liver enzyme activities ALP, AST and ALP were significantly increased (p <0.05) in Lincomycin treated group, while haemoglobin concentration, packed cell volume, white blood cell counts, high density lipoproteins were significantly decreased (p <0.05) in the same group when compared with the three other groups: control , vitamins ,Lincomycin and vitamins groups. Vitamins C and vitamin E were suppressed the oxidative stress of Lincomycin which used in this study, so the data of the present study suggest that, vitamin C and vitamin E could be useful for reducing the detrimental effects of Lincomycin-induced toxicity on liver and kidneys.
KEYWORDS:
Vitamins C and E, Lincomycin, Physiological properties, Biochemical properties, Liver enzymes.
Cite:
Saher Mahmood Jwad, Bushra Abbas, Haider S. Jaffat. Study of The Protective Effect of Vitamin C plus E on Lincomycin-Induced Hepatotoxicity and Nephrotoxicity. Research J. Pharm. and Tech. 8(2): Feb. 2015; Page 177-184.
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