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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   8

Issue No. :  2

Year :  2015

Pages :   167-171

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Isolation and characterization of drug resistant Salmonella typhi from sewage water



Address:   Vanka Kanth Swaroop, Aparna Mukherjee, Sumit Sharma, William Jabez Osborne*
Microbial Bioremediation Lab, School of Bioscience and Technology, VIT University Vellore- 632014 India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2015.00030.X

ABSTRACT:
Salmonella entericaserovar typhi (S. typhi) is a facultative intracellular pathogen, causes typhoid fever in humans. Emergence of fluoroquinolones resistant strains is one of the major public health concern, reports revealed the occurrence of drug resistant strains with increasing minimum inhibitory concentration (MIC) of Ciprofloxacin have shown fatal effects and has led to treatment failures against S .typhi. The present study was focused on isolation of drug resistant S. typhi from various sewage samples. A totally four different drug resistant isolates were obtained on SSA plates supplemented with 200 µgL-1cefixime, a third generation drug used in the treatment of typhoid. The minimal inhibitory concentration was tested for the isolates and the isolate VITSSAJ3 was found to be resistant up to a concentration of 8000 µgL-1.
KEYWORDS:
Salmonella spp., Cefixime, minimum inhibitory concentration (MIC), drug resistance. Isolation and characterization of drug resistant Salmonella typhi from sewage water.
Cite:
Vanka Kanth Swaroop, Aparna Mukherjee, Sumit Sharma, William Jabez Osborne. Isolation and characterization of drug resistant Salmonella typhi from sewage water. Research J. Pharm. and Tech. 8(2): Feb. 2015; Page 167-171.
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