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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   8

Issue No. :  12

Year :  2015

Pages :   1733-1739

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Liquisolid Technology: A Novel Approach to Enhance Solubility of Poorly Water Soluble Drugs



Address:   Bhumi B. Patel1*, Dr. Chainesh N. Shah2, Dr. Rumit M. Shah2, Dr. Dhiren P. Shah3
1M. Pharm., Department of Pharmaceutics, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh - 394 345, Gujarat, India.
2Assistant professor, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh - 394 345, Gujarat, India.
3Principal, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh - 394 345, Gujarat, India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2015.00311.X

ABSTRACT:
Solubility, Dissolution rate and Bioavailability are the main parameters on which therapeutic effectiveness of a drug depends. The limited solubility of drug is challenging point during development of the ideal solid dosage form. Liquisolid system is a novel and promising approach to enhance aqueous solubility, dissolution rate as well as bioavailability of water insoluble solid drugs or liquid lipophilic drugs by conversion of liquid drugs, drug suspensions or drug solution in non-volatile solvents, into dry, non-adherent, free flowing and compressible powder mixtures by simple blending with selected carriers and coating materials. This technology is based on a new mathematical model proposed by Spireas et al. The three main proposed mechanisms by which bioavailability of drug is increased that are increased surface area of drug, increase aqueous solubility of drug and improved wettability of the drug.
KEYWORDS:
Poorly Soluble Drugs, Liquisolid System, Carrier and Coating Material, Wettability, Solubility.
Cite:
Bhumi B. Patel, Chainesh N. Shah, Rumit M. Shah, Dhiren P. Shah. Liquisolid Technology: A Novel Approach to Enhance Solubility of Poorly Water Soluble Drugs. Research J. Pharm. and Tech. 8(12): Dec., 2015; Page 1733-1739.
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