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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   8

Issue No. :  12

Year :  2015

Pages :   1609-1614

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Dyslipidemic and Antioxidant activity of Piper longum extract in hyperlipemic rats



Address:   Dr. Prabha Verma1, Dr. Suresh Kumar Sutrakar2
1Lecturer & Head, Department of Biochemistry, M.L.B. Medical College, Jhansi (U.P) India-284001
2Associate Professor, Department of Pathology, S.S. Medical College and Asso. S.G.M. Hospital, Rewa (M.P.) India-486001
*Corresponding Author
DOI No: 10.5958/0974-360X.2015.00288.7

ABSTRACT:
The dyslipidemic and antioxidant activity of Piper longum extract has been studied in triton and high fat diet fed hyperlipemic rats. The extract lowered the serum lipids at (200 mg/kg, b.w., p.o.) in triton WR-1339 induced hyperlipidemia. Chronic feeding of this extract (100 mg/kg, b.w.) in animals simultaneously fed with high fat diet (HFD) for 30 days caused lowering of lipid and apoproteins level of lipoproteins in experimental animals. P. langum activates lipolytic enzymes in plasma and liver lipids. These extract increased faecal bile acid extraction and enhanced plasma lecithin: cholesterol acyltransferase activity. Piper langum extract showed potent inhibition of antioxidant and scavenger of oxygen free radical activity (in vitro) and it induced oxidative stress.
KEYWORDS:
Hypolipidemic, Triton WR-1339, Antioxidant, Lipid lowering activity.
Cite:
Prabha Verma, Suresh Kumar Sutrakar. Dyslipidemic and Antioxidant activity of Piper longum extract in hyperlipemic rats. Research J. Pharm. and Tech. 8(12): Dec., 2015; Page 1609-1614.
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