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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   8

Issue No. :  11

Year :  2015

Pages :   1512-1518

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Conception and Evaluation of Extended Release Multiparticulate System of Milnacipran Hydrochloride



Address:   Siddharth Yerunkar1*, Mukesh Ratnaparkhi2, Mahesh Bhadgale2, Pramod Parshuramkar2
1Department of Pharmaceutics, Marathwada Mitra Mandal’s College of Pharmacy, Thergaon, Pune -411033, Affiliated to Savitribai Phule Pune University, Pune MS
2Formulation Research and Development, Centaur Pharmaceutical Pvt. Ltd., Hinjewadi Pune, India
*Corresponding Author
DOI No: 10.5958/0974-360X.2015.00270.X

ABSTRACT:
Milnacipran HCl is a selective norepinephrine and serotonin reuptake inhibitor well used drug for the treatment of depression and fibromyalgia. Milnacipran HCl belongs to biopharmaceutical class I having short elimination half-life. Milnacipran HCl recommended immediate release [IR] dose 50mg twice a day associated with frequent dosing which cause side effects, lack of patient compliance and discontinuation of therapy. To overcome such problems, the aim of the present study was to design novel once a day extended release multiparticulate system of Milnacipran HCl using Fluidized bed processor wurster coating technique. To achieve the goal, drug solution layering was done on seal coated #25 – 30 non pareil sugar spheres followed by release controlling polymer coating of Ethyl cellulose and Hydroxypropyl methyl Cellulose in the ratio 90:10 respectively. In vitro dissolution study of 10, 12, and 14% release controlling polymer coated pellets was carried in distilled water using USP type II dissolution apparatus with sinkers. Ratio of hydrophobic to hydrophilic polymer and level of coating have highest effect on drug release. Milnacipran HCl release extended for longer duration as percent of release controlling polymer coating increased. The release kinetics was explored and explained with zero order, first order, Higuchi and Korsmeyer equations. The drug release from pellets has no significant effect of pH of dissolution medium.
KEYWORDS:
Milnacipran HCl, Extended release pellets, Ethyl Cellulose, Hydroxypropyl methyl Cellulose.
Cite:
Siddharth Yerunkar, Mukesh Ratnaparkhi, Mahesh Bhadgale, Pramod Parshuramkar. Conception and Evaluation of Extended Release Multiparticulate System of Milnacipran Hydrochloride. Research J. Pharm. and Tech. 8(11): Nov., 2015; Page 1512-1518.
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