2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   8

Issue No. :  10

Year :  2015

Pages :   1412-1416

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Protective Effect of Hexane Extract of Trachyspermum ammi Linn in Carbon Tetra Chloride-Induced Hepatitis in Rats



Address:   Avinash Suryawanshi*, Dr. Yadunath Joshi, Dr. Ashish Jain, Dr. Vilasrao Kadam
Department of Pharmacology, Shri D.D. Vispute College of Pharmacy and Research Center, Devad-Vichumbe, New Panvel, Maharashtra, India.
*Corresponding Author
DOI No: 10.5958/0974-360X.2015.00254.1

ABSTRACT:
Objectives: To evaluate the hepatoprotective activity of hexanolic extract of leaves of Trachyspermum ammi linn were studied against Wister rats with liver damage induced by carbon tetrachloride (CCl4) Methods: The hepatoprotective effect of the hexanolic extract is measured against Wister rats with liver damage induced by carbon tetrachloride (CCl4) through measuring the serum levels of Aspartate aminotransaminase (AST), Alanine aminotransaminase (ALT) and alkaline phosphatase (ALP) and Bilirubin to a significant extent. The hexanolic extract was screened for toxicity by oral toxicity studies according to OECD guidelines 423. LD 50 was calculated for selection of dose. The liver samples were dissected out, blotted off blood, washed with saline and also stored it in 10% formalin and proceeded for histopathology to evaluate the details of hepatic architecture in each group microscopically. Results: Administration of Trachyspermum ammi Linn (Dose 250mg/kg, 500mg/kg s.c) significantly prevented carbon tetrachloride induced elevation of serum ALT, AST, ALP and bilirubin level. Histological examination of the liver section revealed hepatic regeneration, after administration of various doses of Trachyspermum ammi Linn. Conclusion: The hexanolic extracts of leaves of Trachyspermum ammi linn showed significant decrease in the levels of serum markers, indicating the protection of hepatic cells, the extract of root of the plant could afford significant dose-dependent protection against CCl4 induced hepatocellular injury.
KEYWORDS:
Hepatoprotective, AST, ALT, ALP, Bilirubin.
Cite:
Avinash Suryawanshi, Yadunath Joshi, Ashish Jain, Vilasrao Kadam. Protective Effect of Hexane Extract of Trachyspermum ammi Linn in Carbon Tetra Chloride-Induced Hepatitis in Rats. Research J. Pharm. and Tech. 8(10): Oct., 2015; Page 1412-1416.
[View HTML]      [View PDF]



Visitor's No. :   646157