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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   8

Issue No. :  10

Year :  2015

Pages :   1454-1462

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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A Review on Oral Extended Release Technology



Address:   D Vamshidhar Reddy*, Dr. Ambati Sambashiva Rao
Sri Indu Institute of Pharmaceutical Sciences, Sheriguda, Ibrahimpatnam, R.R Dist. 501 510
*Corresponding Author
DOI No: 10.5958/0974-360X.2015.00261.9

ABSTRACT:
In recent decades pharmaceutical industries are focusing on development of extended release formulations due to its various advantages. The drugs which are having the shorter half-life and high dosing frequency are suitable for extended release formulations. Extended release drug delivery system which reduce the dosing frequency of certain drugs by releasing the drug at slow rate and extended period of time. This formulation helps to avoid the side effects associated with low and high concentrations. The ideal order release rate and maintain the constant plasma concentrations. The extended release formulations may maintain therapeutic concentrations over prolonged periods. The use of extended release formulations avoids the high blood concentration. Extended release formulations have the potential to improve the patient compliance, reduce the toxicity by slowing drug absorption, minimize drug accumulation with chronic dosing, usage of less total drug and reduce the dose frequency, improvement the bioavailability of some drugs. Developing oral extended release tablets for drug at constant release rate has always been a challenge to the pharmaceutical technologist. There are various physicochemical and biological properties which affect the extended release dosage form. This article discusses the recent literature regarding development and design and fabrication of extended release system and in-vitro performance of extended release formulation.
KEYWORDS:
Extended Release, Oral Drug Delivery System, Design of Extended Release Dosage forms.
Cite:
D Vamshidhar Reddy, Ambati Sambashiva Rao. A Review on Oral Extended Release Technology. Research J. Pharm. and Tech. 8(10): Oct., 2015; Page 1454-1462.
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