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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  9

Year :  2014

Pages :   1038-1040

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Validation of UV-Spectroscopic method for the Estimation of Bicalutamide in Pure and Pharmaceutical Dosage Form



Address:   Sowmya Manala1*, Alivelu Samala2, M. Sasikala2, Kishore Chatlapelli3
1Department of Pharmaceutical Analysis, Priyadarshini College of Pharmaceutical Sciences, Chowdaryguda (V), Ghatkesar (M), Hyderabad AP.
2Department of Pharmaceutical Chemistry, Holy Mary Institute of Pharmacy, Bogaram (V), Keesara (M). Hyderabad AP.
3Department of Pharmaceutics. Holy Mary Institute of Pharmacy, Bogaram (V), Keesara (M), Hyderabad AP.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The present research work discusses the development of a UV estimation method for Bicalutamide. A simple, accurate, rapid, sensitive and precise UV spectrophotometric method has been developed for the estimation of Bicalutamide in pure and pharmaceutical dosage forms. Beer’s law was obeyed in the range of 2.5-15 microgram/ml at 272nm and shows a correlation coefficient of 0.999.The concentrations of this drug were evaluated in laboratory mixture and marketed formulation. Accuracy was determined by recovery studies from tablet dosage form and ranges from 99.6 to 100.2 %. Precision of present method was find out as repeatability, day to day and shows the values within acceptable limit.
KEYWORDS:
Bicalutamide, UV spectrophotometer, Validation, Beer’s law.
Cite:
Sowmya Manala, Alivelu Samala, M. Sasikala, Kishore Chatlapelli. Development and Validation of UV-Spectroscopic method for the Estimation of Bicalutamide in Pure and Pharmaceutical Dosage Form. Research J. Pharm. and Tech. 7(9): Sept. 2014 Page 1038-1040.
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