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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  9

Year :  2014

Pages :   1025-1028

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Anti-Microbial Activity of Some Novel Mannich Base Aryl Imidazole Derivatives



Address:   K. Girija1*, S. Karthika1, Nisha Mathew2
1Department of Pharmaceutical Chemistry, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences,(A Govt. of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry-605 006
2Vector Control Research Center [ICMR], Indira Nagar Complex, Gorimedu, Puducherry-605 006
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Mannich base aryl imidazole derivatives were synthesized by condensing Primary aromatic amines and Aryl aldehydes in presence of glacial acetic acid to give respective Schiffs bases, which on further treatment with Ammonium acetate and Isatin in presence of glacial acetic acid to produce aryl imidazoles followed by stirring with formaldehyde and primary amines for 1 hour in presence of ethanol to yield the corresponding Mannich bases. The purity of the synthesized compounds were checked by TLC and characterized by FT-IR, Mass spectroscopy. All the synthesized compounds were evaluated for the Anti-bacterial and Anti-fungal activity. The compounds 1a, 1b, 1c, 1e, 2a showed good antibacterial activity against Staphylococcus aureus and E.coli compared to standard Ciprofloxacin. The compounds 1a, 1c, 2a showed good antifungal activity against Candida albican compared to standard Amphotericin B.
KEYWORDS:
Aryl Imidazoles, Mannich Base, Primary Amines, Formaldehydes, Antibacterial And Antifungal, Ciprofloxacin, Amphotericin B.
Cite:
K. Girija, S. Karthika, Nisha Mathew. Synthesis and Anti-Microbial Activity of Some Novel Mannich Base Aryl Imidazole Derivatives. Research J. Pharm. and Tech. 7(9): Sept. 2014 Page 1025-1028.
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