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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  9

Year :  2014

Pages :   995-998

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Biological Evaluation of Some Novel Pyrimidine Derivatives Derived from Chalcones



Address:   K. Ishwar Bhat, Abhishek Kumar*, Pankaj Kumar and Riyaz E.K
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences ,Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A series of novel 6-(substituted phenyl)-4-(nitrophenyl) pyrimidin-2-ol (RPY1-RPY8) have been synthesized upon refluxing with 3-(4-nitrophenyl)-1-phenyl substituted prop-2-en-1-one in presence of thiourea and glacial acetic acid. 3-(4-nitrophenyl)-1-phenyl substituted prop-2-en-1-one (RC1-RC8) were prepared by reaction with 4-nitrobenzaldehyde and substituted acetophenones in presence of NaOH. The structures of the final synthesized compounds were confirmed by IR, 1H NMR and mass spectra. All the new compounds were screened for their in-vitro antimicrobial, antitubercular and cytotoxic activities. Most of the compounds have exhibited promising antibacterial, antifungal, antitubercular and cytotoxic activities.
KEYWORDS:
Chalcones, pyrimidines, antibacterial activity, antifungal activity, antitubercular activity, cytotoxic activity
Cite:
K. Ishwar Bhat, Abhishek Kumar, Pankaj Kumar, Riyaz E.K. Synthesis and Biological Evaluation of Some Novel Pyrimidine Derivatives Derived from Chalcones. Research J. Pharm. and Tech. 7(9): Sept. 2014 Page 995-998.
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