2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  9

Year :  2014

Pages :   973-975

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Formulation and Invitro Evaluation of Gastroretentive Floating Tablets of Ivabradine Hydrochloride using Different Polymers.



Address:   Senthil. S.P1, Sreeja. M.K1, Jerin Vincent2, Manoj Kumar Singh2
1Dept.of Pharmaceutics, Erode College of Pharmacy and Research. Erode, Tamil Nadu 2 Bafna Pharmaceuticals Ltd., Chennai.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The study was aimed on preparing gastro retentive floating tablets with Ivabradine HCl using different polymers such as HPMC K 100 and Xanthan gum. Sodium bicarbonate and citric acid were used as gas generating agents. Tablets was prepared by direct compression methodand subjected to various evaluation parameters like hardness, thickness, friability, weight variation, drug content uniformity, floating lag time, floating duration time, invitro release studies. Release kinetics was explained with zero order, first order, Higuchi and Peppas kinetics. The optimized formulation was F8 and it showed an invitro drug release of 99.84% at the end of 8th hour, following Peppas kinetics for the release.
KEYWORDS:
Ivabradine HCl, HPMC K100, Xanthan gum, Floating tablets.
Cite:
Senthil. S.P, Sreeja. M.K, Jerin Vincent, Manoj Kumar Singh. Formulation and Invitro Evaluation of Gastroretentive Floating Tablets of Ivabradine Hydrochloride using Different Polymers. Research J. Pharm. and Tech. 7(9): Sept. 2014 Page 973-975.
[View HTML]      [View PDF]



Visitor's No. :   644524