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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  9

Year :  2014

Pages :   999-1003

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Evaluation of Stability Parameters for Calcium Carbonate Antacid Suspension using Different Concentrations of Suspending Agents



Address:   Dharmendra Rajput, Anuradha Verma, Azra Qureshi, Sonam Singh, Bhavana Yadav, Naveen Das Manikpuri, Sonal Daniel, Pelesh Kumar Sahu, B. Rajgopal, Shailendra Nayak, Jaideep Dewangan, Kamal Deo Sahu, D. K. Tripathi, Amit Alexander, Ajazuddin*
Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud, Bhilai, Chhattisgarh, India, 490024
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Calcium carbonate is non-systemic antacid and its reaction with HCl in the stomach is not as rapid for this reason it produces a more prolong reduction in gastric acidity. Present work is to establish a method to prepare a stable antacid suspension using different suspending agent, the suspending agents are essential for better stability of a suspension. Hence, an attempt is made to identify the suitable suspending agent and its optimum concentration for antacid formulation. Gelatin, Tragacanth, Guar gum, Acacia and Bentonite have been studied at different concentrations. Observations depict that suspension using acacia as suspending agent shows flow rate 1.25, 1 and 0.83 ml/sec, viscosity 1.25, 1.40 and 1.59 poise, pH 6, 7 and 7, and sedimentation volume 0.06, 0.1 and 0.2 for the concentrations 1%,1.5% and 2% respectively. Observation of these stability parameters shows that acacia is a better suspending agent in comparison to other as it gives minimum degree of flocculation and sedimentation volume in comparison to other at the optimum concentration that is 2 % concentration.
KEYWORDS:
Suspension, Suspending agent, Antacid, Sedimentation, Stability.
Cite:
Dharmendra Rajput, Anuradha Verma, Azra Qureshi, Sonam Singh, Bhavana Yadav, Naveen Das Manikpuri, Sonal Daniel, Pelesh Kumar Sahu, B. Rajgopal, Shailendra Nayak, Jaideep Dewangan, Kamal Deo Sahu, D. K. Tripathi, Amit Alexander, Ajazuddin. Evaluation of Stability Parameters for Calcium Carbonate Antacid Suspension using Different Concentrations of Suspending Agents. Research J. Pharm. and Tech. 7(9): Sept. 2014 Page 999-1003.
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