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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  9

Year :  2014

Pages :   1091-1098

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Adverse Drug Reactions: Predisposing Factors, Modern Classifications and Causality Assessment



Address:   Abdullahi Rabiu Abubakar1, Nordin Bin Simbak2, Mainul Haque3*
1Masters Student, Unit of Pharmacology, Faculty of Medicine and Health Sciences (FPSK), Universiti Sultan Zainal Abidin (UniSZA), 20400 Kuala Terengganu, Terengganu, Malaysia
2Professor and Dean, FPSK, UniSZA, 20400, Kuala Terengganu, Malaysia
3Professor, Head of the Unit of Pharmacology, FPSK, UniSZA, 20400 Kuala Terengganu, Terengganu, Malaysia.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Many factors predispose patient to develop adverse drug reactions (ADRs), some of these factors are drug related, patient related, disease related, social and adverse drug related. The contributions of these factors to development of ADRs are very crucial and are well documented in medical literature. It has become necessary for every medical practitioner to consider these factors in order to prescribe the best medication to his patients. The current classification of ADRs is only based on drug known pharmacology and dose dependent of its action. In order to give comprehensive classification, the time course of its appearance and its severity as well as patient susceptibility are taken into consideration. Knowledge of causality assessment enables the medical practitioners to clarify the likelihood that the suspected adverse drug reaction is actually due to the medicine. This requires careful patient monitoring because adverse drug reaction can be difficult and a times impossible to distinguish from patient disease condition. The purpose of this article is to review the factors affecting the development of ADRs, its broader classification and to assess causal relationship between the suspected drug and appearance of ADRs.
KEYWORDS:
Adverse drug reactions, adverse drug event, predisposing factors, modern classification, causality assessment and Naranjo probability score
Cite:
Abdullahi Rabiu Abubakar, Nordin Bin Simbak, Mainul Haque. Adverse Drug Reactions: Predisposing Factors, Modern Classifications and Causality Assessment. Research J. Pharm. and Tech. 7(9): Sept. 2014 Page 1091-1098.
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