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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  9

Year :  2014

Pages :   1046-1051

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and characterization of karanj oil based proniosomal gel for topical delivery



Address:   Nurul Diana Dzaraly1, Nor Iza A. Rahman2*, Nordin Bin Simbak3, Suhaimi Ab. Wahab4, Omar Osman5, Salwani Ismail6, Mainul Haque7
1Masters Student, Faculty of Medicine and Health Science (FPSK), Universiti Sultan Zainal Abidin (UniSZA), 20400 Kuala Terengganu, Malaysia
2Medical Lecturer and Head of the School of Basic Medical School, FPSK, UniSZA, 20400 Kuala Terengganu, Malaysia
3Professor and Dean, FPSK, UniSZA, 20400 Kuala Terengganu, Malaysia
4Medical Lecturer and Deputy Dean, PPSP, Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
5Professor and Vice Chancellor, Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia
6Medical Lecturer and Deputy Dean, FPSK, UniSZA, 20400 Kuala Terengganu, Malaysia
7Professor and Head of the Unit of Pharmacology, FPSK, UniSZA, Kampus Kota, 20400 Kuala Terengganu, Terengganu, Malaysia.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Niosomes are non-ionic surfactant vesicles which act as drug carrier system for topical delivery. In the present study, we carried preparation and evaluation of proniosomal gel of karanj oil (Derris indica family -Fabaceae). Karanj oil is traditionally used for the treatment of eczema, leprosy and some common skin infection. The proniosomal gel was prepared by slurry method using span 40, soya lecithin and cholesterol, using karanj oil as the active pharmaceutical ingredients. Alcohol and phosphate buffer pH 7.4 were used in formulation as pharmaceutical excipients. The resulting formulations were evaluated and observed by transmission electron microscopy. Evaluation of formulation confirmed the optimum result like uniform size distribution (150nm-330nm), drug entrapment (70-75%) and antimicrobial property. It can be concluded that it is visible to prepare an acceptable proniosomal gel of karanj oil for therapeutic application.
KEYWORDS:
Topical delivery, proniosomal gel, karanj oil, slurry method.
Cite:
Kumar Bandhu Lathiyare, Vishal Jain. Development and characterization of karanj oil based proniosomal gel for topical delivery. Research J. Pharm. and Tech. 7(9): Sept. 2014 Page 1052-1059.
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