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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  8

Year :  2014

Pages :   876-881

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Characterization of Olanzapine Immediate Release Tablets by using Natural Super Disintegrants



Address:   V. Kalyani*, V. Sai Kishore, U. Kartheek, D. Mounica, S. Sri Lakshmi
Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur District AP India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
In the present study, natural gums (Banana powder and Modified gum karaya) were investigated as superdisintegrants for use in immediate release tablet formulations containing olanzapine. Immediate release tablets of olanzapine were formulated using different concentrations (2, 3, 4, 5) of natural superdisintegrant viz; Banana powder and modified gum karaya. Prepared tablets were evaluated for thickness, hardness, friability, uniformity of weight, disintegration time, wetting time and dissolution study. The formulated tablets had good appearance and better drug release properties. Modified gum karaya showed shorter disintegration time and showed 100% release is selected as optimized formulation. Immediate release tablet formulations containing modified gum karaya showed better dissolution efficiency property than the most widely used synthetic superdisintegrants. The dissolution rate followed first-order kinetics as the graphs drawn between log % drug unreleased vs time were found to be linear. The dissolution rate of Olanzapine was found to be effected by the concentration of the superdisintegrant used in the preparation of tablets. The formulation (F4) prepared with 5%w/w of modified gum karaya was offered relatively rapid release of Olanzapine when compared with other concentrations employed in this investigation. The difference factor (f1) and similarity factor (f2) were calculated for marketed formulation and for formulations prepared with modified gum karaya. The difference factor (f1) and similarity factor (f2) were found to be 13 and 71 respectively. Similarity factor (f2) is more than 50 and difference factor (f1) is less than 15, hence dissolution profiles are found to be similar.
KEYWORDS:
: Olanzapine, Modified gum Karaya, Banana powder, Crospovidone.
Cite:
V. Kalyani, V. Sai Kishore, U. Kartheek, D. Mounica, S. Sri Lakshmi. Formulation and Characterization of Olanzapine Immediate Release Tablets by using Natural Super Disintegrants. Research J. Pharm. and Tech. 7(8): August 2014 Page 876-881.
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