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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  8

Year :  2014

Pages :   856-863

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development of quality Indicators of liposomal Preparations "EFIAL"

Address:   Borshchevskiy G.I.1, Yarnykh T.G.2, Konovalenko V.A.1, Chabaniy V.N.1
1PJSC "Pharmak", Kiev National University of Pharmacy, Kharkov
2Professor, Head of the Department of Drug Technology, National University of Pharmacy, Kharkov- 61168
*Corresponding Author
DOI No: Not Available

Phospholipids recently considered only as an object of chemical, biophysical, physiological studies. However, some properties, such as the ability to form isolated volumes in an aqueous medium, lowering the surface energy of the phase, but also technology development phospholipids from natural raw materials have allowed their use in the preparation of various drugs. One promising area of application is the creation of phospholipid liposomal formulations that imitate natural ekzosomes mechanism of intercellular communication. "Efial" spray is an emulsion of a yellowish color, which includes: concentrate deproteinization dermal layer of the skin of pigs, phosphatidylcholine from soybean and auxiliaries. As preservative is used the sodium salt of propyl parahydroxybenzoate and metilgidrobenzoata. It is known that phospholipid liposomes significantly affect the properties of the liposomes and therefore requires a thorough physical and chemical analysis , which is particularly important at the stage of intra- stage control. The aim of this work is to develop techniques basic quality spray "Efial". In accordance with the requirements of SPhU held standardization Efial preparation, spray for external use. Methods have been developed to identify and quantify the active ingredients of the drug "Efial", using high performance liquid chromatography. Quality indicators can characterize the efficacy and safety "Efial" within the expiry date.
Phospholipids, liposoms, indicators of quality, technology.
Borshchevskiy G.I., Yarnykh T.G., Konovalenko V.A., Chabaniy V.N. Development of quality Indicators of liposomal Preparations "EFIAL". Research J. Pharm. and Tech. 7(8): August 2014 Page 864-869.
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