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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  8

Year :  2014

Pages :   840-844

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation, Optimization and Evaluation of Amlodipine Besylate Sublingual Films



Address:   Mayur V. Chinchore*, Pankaj D. Kothawade, Rajendra K. Surwase, Avish D. Maru
Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Tal- Kalwan, Dist- Nashik (423501), Maharashtra, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Amlodipine is widely used in the treatment of Hypertension, Angina pectoris and Cardiac arrhythmia. The present study is deals with formulation, optimization evaluation of Amlodipine sublingual films. Hypertension, Angina pectoris and Cardiac arrhythmia are the conditions where instance effect of drug is required. Amlodipine is one of the drug which is used in the treatment of above three disease conditions. The sublingual films was prepared by using solvent casting method. The concentration of polyvinyl alcohol (PVA), glycerin, sodium lauryl sulphate (SLS) were kept constant in all formulations (F1-F9) and varying concentration of hydroxy propyl methyl cellulose(HPMC). All the formulations were evaluated for surface pH, weight uniformity, folding endurance, drug content, disintegration time, in-vitro dissolution studies. The formulation ‘F5’ was found to be optimized formulation. It shows results for all evaluation parameters such as weight variation 90.10±0.16 mg, surface pH 6.75±0.60, folding endurance > 100, drug content 98.60±0.60%, disintegration time 17±0.30 sec, and in-vitro dissolution study 98.78 % at the end of 5 min.
KEYWORDS:
Sublingual films, Amlodipine besylate, Solvent casting, Hypertension, Angina pectoris, Cardiac arrhythmia.
Cite:
Mayur V. Chinchore, Pankaj D. Kothawade, Rajendra K. Surwase, Avish D. Maru. Formulation, Optimization and Evaluation of Amlodipine Besylate Sublingual Films. Research J. Pharm. and Tech. 7(8): August 2014 Page 840-844.
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