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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  7

Year :  2014

Pages :   792-797

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Fast Disintegrating Tablet of Eletriptan Hydrobromide



Address:   Ashok P. Pingale1* Suvarna A. Katti2 , R.K. Choudhari2, R.S. Bhambar2
1Department of Pharmaceutical Chemistry, M.V.P. Samaj’s College of Pharmacy, University of Pune, Gangapur Road Nasik
2Department of Quality Assurance, M.G.V’s Pharmacy College, Panchavati, Nashik-422003
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The present work emphasizes the study of disintegrant property of a superdisintegrant Sodium Starch Glycolate and a Croscarmellose sodium and the effect of their varying concentrations on disintegration time and drug release. FDT’s were prepared using Eletriptan Hydrobromide as a model drug. 32 factorial design was used by which nine formulations were prepared using direct compression technique. The tablets were evaluated for drug content, friability, hardness, wetting time, water absorption ratio, in vitro disintegration time, and dissolution profile. It was observed that all the formulations were acceptable with reasonable limits of standard required for fast dissolving tablets. It was concluded that optimal concentration of Sodium starch glycolate as a superdisintegrant is 5.06% and Croscamellose sodium is 3.33% (F9), showing best DT and drug release.
KEYWORDS:
Fast Disintegrating Tablet, Eletriptan Hydrobromide, Superdisintegrant, direct compression.
Cite:
Ashok P. Pingale, Suvarna A. Katti, R.K. Choudhari, R.S. Bhambar. Formulation and Evaluation of Fast Disintegrating Tablet of Eletriptan Hydrobromide. Research J. Pharm. and Tech. 7(7): July 2014 Page 792-797.
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