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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  6

Year :  2014

Pages :   638-642

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development of UV Spectrophotometric method for the analysis of Antipsychotic drug



Address:   Mohd Yasir1,2*, UVS Sara3
1Department of Pharmacy, Uttarakhand Technical University, Dehradun-248007 (Uttarakhand), India
2Department of Pharmaceutics, ITS Pharmacy College, Delhi –Meerut Highway, Muradnagar, Ghaziabad – 201206 (UP), India
3College of Pharmaceutical Sciences, RKGIT, Delhi –Meerut Highway, Ghaziabad, 201201 (UP), India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The aim of the present work was to develop and validate a sensitive, simple, accurate, precise and cost effective UV spectrophotometric method for the analysis of antipsychotic drug i.e haloperidol in prepared pharmaceutical formulations of solid lipid nanoparticles. The different analytical performance parameters such as linearity, range, precision, accuracy, limit of detection (LOD) and limit of quantification (LOQ) were determined according to International Conference on Harmonization (ICH) Q2 (R1) guidelines. The study was performed in phosphate buffer of pH 7.4. The peak (Lambda max) of haloperidol appeared at a wavelength of 247.5 nm in Phosphate buffer (pH 7.4). Beer-Lambert’s law was obeyed in the concentration range of 2–20 microgram/ml with correlation coefficient (R2) 0.9994. The results of the study demonstrated that the developed procedure is accurate, precise and reproducible (relative standard deviation <2%), while being simple, cheap and less time consuming. The results of stability study indicate that the drug was stable in selected medium after storage up to 48 h and was not affected by light and dark cycles. Therefore, this method can be suitably applied for the estimation of haloperidol in prepared solid lipid nanoparticles.
KEYWORDS:
Antipsychotic drug, haloperidol, stability, UV spectrophotometric method, validation.
Cite:
Mohd Yasir, UVS Sara. Development of UV Spectrophotometric method for the analysis of Antipsychotic drug. Research J. Pharm. and Tech. 7(6): June, 2014; Page 638-642.
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