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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  5

Year :  2014

Pages :   533-536

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Spectrophotometric Estimation of Ambroxal hydrochloride in Bulk Drug and Pharmaceutical Dosage Form by Area Under Curve Method



Address:   Rele Rajan V.*
Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai 400016 *Corresponding Author
DOI No: Not Available

ABSTRACT:
A simple and precise UV- spectrophotometric method, area under curve [AUC], has been developed and validated for the estimation of ambroxal hydrochloride in bulk drug and its pharmaceutical formulation. Ambroxal hydrochloride was estimated by area under curve (AUC) method for the zero order spectrums in between 205 nm to 214 nm. Beer’s law was obeyed in the concentration range of 1 to 10 miicrogram / ml with coefficient of correlation value 0.9995. This method was tested and validated for various parameters according to ICH guidelines. The precision expressed as relative standard deviation, which was within the range of 0.2011 % to 1.3330 % for the above method. The proposed method was successfully applied for the determination of ambroxal hydrochloride in pharmaceutical formulation. Results of the analysis were validated statistically and were found to be satisfactory. The proposed method is simple, easy to apply, low-cost and require relatively inexpensive instruments.
KEYWORDS:
Ambroxal hydrochloride, Area under curve method.
Cite:
Rele Rajan V. Spectrophotometric Estimation of Ambroxal hydrochloride in Bulk Drug and Pharmaceutical Dosage Form by Area Under Curve Method. Research J. Pharm. and Tech. 7(5): May, 2014; Page 533-536.
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