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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  3

Year :  2014

Pages :   322-327

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Dose dependent anxiolytic activity of verapamil in mice in comparison to saline and fluoxetine



Address:   Margaret Shanthi F.X.1*, Aniket Kumar2, Febina Bernice2, Kalpana Ernest2
1Associate Professor, Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Bagayam, Vellore-02, TamilNadu
2Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, Tamilnadu, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Objective: To evaluate anxiolytic like effect of Verapamil in mice. Materials and Methods: Verapamil was administered at two different doses (10mg and 20mg mg/kg BW) once daily for 9 days to Swiss albino mice of either sex. The anxiolytic activity of control and drug treated mice were recorded by light and dark exploration, marble burying and social interaction method. The anxiolytic effect of verapamil in two doses and in combination with fluoxetine was compared to that of fluoxetine (20 mg/kg BW) administered for 9 successive days. Results: Combination of both drugs and Verapamil alone produced significant anxiolytic effect at two doses (10mg and 20mg /kg), as indicated by decrease in marble burying, changes in light and dark exploration and increase in social interaction, of drug-treated mice compared to control mice. The efficacy of combinational drugs and Verapamil at 20mg/kg was comparable to that of Fluoxetine, but anxiolytic activity in animals administered with Verapamil 10mg/kg was significantly less as compared to Fluoxetine pre-treated mice. Conclusion: The results of the present study indicate anxiolytic like activity of Verapamil.
KEYWORDS:
Anxiolytic, Verapamil, Calcium channel blockers, Fluoxetine, Marble burying.
Cite:
Margaret Shanthi F.X., Aniket Kumar, Febina Bernice, Kalpana Ernest. Dose dependent anxiolytic activity of verapamil in mice in comparison to saline and fluoxetine. Research J. Pharm. and Tech. 7(3): Mar., 2014; Page 322-327.
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