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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  3

Year :  2014

Pages :   290-295

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Sustained Release Matrix Tablets of Acyclovir



Address:   Mohammed Asif Hussain*, K. Sravan, Maimuna Anjum, Nusrath Ayesha
Blue Birds College of Pharmacy, Bheemaram, Hanamkonda-506015
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Sustained release is providing promising method to be able to decrease the unwanted effects of drugs by preventing the fluctuation of the therapeutic concentration of the drugs in the body. The aim of current study was to design and characterization of sustained release matrix tablets of Acyclovir by using Hydroxylpropylmethylcellulose (HPMC K100M, K15M, K4M) and Sodium Alginate, by direct compression method. The matrix tablets were then evaluated for various physical tests like, Thickness, Uniformity of weight, hardness, friability, drug content and in vitro drug release. The calculated regression coefficient has shown higher r2 values with zero order kinetics and higuchi kinetics. The ā€˜nā€™ values of most of the formulations has shown non-fickian diffusion.
KEYWORDS:
Acyclovir, sustained release matrix tablet, Direct compression technique, HPMC, Sodium Alginate.
Cite:
Mohammed Asif Hussain, K. Sravan, Maimuna Anjum, Nusrath Ayesha. Formulation and Evaluation of Sustained Release Matrix Tablets of Acyclovir. Research J. Pharm. and Tech. 7(3): Mar., 2014; Page 290- 295.
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