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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  3

Year :  2014

Pages :   284-289

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Liquisolid Compact on NSAID Naproxen



Address:   Mohan Dhere1*, Niranjan D. Chivate2, Anuradha N. Chivate3
1Department of Pharmaceutics, Sant Gajanan Maharaj College of Pharmacy Mahagaon, Site-Chincewadi Tal-Gadhingaj, Dist-Kolhapur 416503, India
2Department of Pharmaceutics, KCT’s Krishna College of Pharmacy, Malkapur , Karad Maharashtra India 3Department of Pharmacology, KES’S Rajarambapu College of Pharmacy, Kasegaon, Dist- Sangli Maharashtra- 415404, India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Liquisolid compacts were used to formulate water insoluble drugs in non-volatile solvents and converting into acceptably flowing and compressible powders. The main objective of present investigation was to enhance the dissolution rate of water insoluble drug naproxen by using liquisolid technique. Several liquisolid tablets were prepared by using different carrier materials such as microcrystalline cellulose (Avicel pH-101), and coating material such as silica gel, respectively. Polyethylene glycol 400 was used as nonvolatile water miscible liquid vehicle. The liquid loading factors for such liquid vehicle was calculated to obtain the optimum amounts of carrier and coating materials necessary to produce acceptable flowing and compactable powder admixtures viable to produce compacts. Before compression, powdered mass were evaluated for various parameters like flow properties, content uniformity etc. All the prepared formulations were compressed using 12mm punch after addition of 5 % Sodium starch glycolate (super disintegrating agent) to each formulation. The formulated liquisolid tablets were evaluated for post compression parameters such as weight variation, hardness, drug content uniformity, percentage friability and disintegration time. The in-vitro release characteristics of the pure drug, drug from marketed tablets (as reference) and liquisolid technique (test sample), were studied. X-Ray Diffraction (XRD) and DSC were performed. The results showed that liquisolid formulations of naproxen exhibited higher percentage of drug release than marketed formulation. And it was concluded that there was no interaction between drug and excipients.
KEYWORDS:
Liquisolid compacts; Naproxen; Dissolution; content uniformity.
Cite:
Mohan Dhere, Niranjan D. Chivate, Anuradha N. Chivate. Formulation and Evaluation of Liquisolid Compact on NSAID Naproxen. Research J. Pharm. and Tech. 7(3): Mar., 2014; Page 284-289.
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