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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  3

Year :  2014

Pages :   275-283

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Development of Mouth Dissolving Tablets of Isolated Molecules and Evaluation for Anti-Hyperglycemic Activity



Address:   Nikhat F.1,3*, Satyanarayana D.2, Sheikh A.S.3 Prajakta H.3, Ajaj A.3
1Department of Pharmaceutical chemistry, NGSMIPS, Deralakatte, Mangalore.
2Department of Pharmaceutical chemistry, VIP Sciences, Rajahmundry, AP.
3Department of Pharmacy, AIKTC School of Pharmacy, New Panvel, Mumbai.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Fast disintegrating drug delivery system offers a solution for those patients who are having difficulty in swallowing oral dosage forms. The present paper deals with formulation and evaluation of fast dissolving tablets from selected medicinal plants (Syzygium cuminii (L) skeel, Momordica charantia Linn Cassia auriculata Linn,) roots. A Pharmaceutical dosage form was made by using a novel constituent isolated from above mentioned plant constituents (ScReX-6b, McReX-1.CaReX-4) without and with excipients by direct compression. The tablets were evaluated for in-vivo and in-vitro anti-hyperglycemic activity and in-vitro hardness, friability, weight variation, disintegration time, water absorption ratio, wetting time and in vitro dissolution studies. All the formulations exhibited disintegration time in the range of 12.2 to 27.5 seconds along with rapid in vitro dissolution. It was concluded that the fast dissolving tablets of the poor soluble drug can be formulated by direct compression technique using selective super disintegrants with enhanced dissolution, taste masking and hence ensuring better patient compliance and effective therapy.
KEYWORDS:
Fast dissolving, Syzygium cuminii (L) skeel, Momordica charantia Linn Cassia auriculata Linn, antihyperglycaemic.
Cite:
Nikhat F., Satyanarayana D., Sheikh A.S., Prajakta H., Ajaj A. Formulation and Development of Mouth Dissolving Tablets of Isolated Molecules and Evaluation for Anti-Hyperglycemic Activity. Research J. Pharm. and Tech. 7(3): Mar., 2014; Page 275-283.
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