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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  2

Year :  2014

Pages :   168-172

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Stability Indicating RP-HPLC Method for Determination of Azilsartan Medoxomil in Pharmaceutical Dosage Form



Address:   Masthanamma S.K.*, Pradeepthi, Jahnavi
Department of Pharmaceutical Analysis, Acharya Nagarjuna University ,Nagarjuna Nagar, Guntur District, Andhra Pradesh, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A simple, fast, accurate and precise reverse phase HPLC method was developed for the separation and quantification of Azilsartan medoxomil in pharmaceutical dosage form. The quantification was carried out using Hypersil BDSC18, 250X4.6 mm, 5µ, enhanced polar selectivity column and mobile phase comprised of potassium dihydrogen phosphate buffer pH adjusted to 4.0 ± 0.5 with orthophosphoric acid and acetonitrile in proportion of ratio 60:40 and degassed under ultrasonication. The flow rate was 1.0mL/min and the effluent was monitored at 248nm. The retention time of Azilsartan medoxomil was 3.8 min .The method was validated in terms of linearity, precision, accuracy, specificity, limit of detection and limit of quantitation as per ICH guide lines. Linearity ofAzilsartan was in the range of 10-60 microgram/mL .The percentage recovery of azilsartan is 99.8% from the tablet formulation.The present method is used for routine quality control of the Azilsartan medoxomil. and in tablet dosage form.
KEYWORDS:
Azilsartan medoxomil, RP-HPLC, tablets, Validation, stability studies.
Cite:
Masthanamma S.K., Pradeepthi, Jahnavi. Stability Indicating RP-HPLC Method for Determination of Azilsartan Medoxomil in Pharmaceutical Dosage Form. Research J. Pharm. and Tech. 7(2): Feb. 2014; Page 168-172.
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