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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  11

Year :  2014

Pages :   1292-1296

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis of Some Active Oxazolidinones Derivatives and Evaluation of their Antimicrobial and Anti-Inflammatory Activities



Address:   Pankaj Kumar*, Jennifer Fernandes and Abhishek Kumar
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Science NITTE University, Deralakatte, Mangalore-575018, Karnataka, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
In order to develop relatively small molecules as pharmacologically active molecules, a series of novel oxazolidinones having benzothiazinen and their derivatives were synthesized, and characterized by IR, 1H NMR and Mass spectral studies. Oxazolidinones were prepared from R-glycidylbutarate and Para bromo aniline. Various substituted oxazolidinones benzothiazinen were prepared by simple reflux in the presence of acetonitrile. Treatment of these oxazolidinones benzo thiazinen deravatives with methanesulfonyl gives its sulphonates derivatives on further treatment wih sodium azide and tri phenyl phosphine in acetic anhydride to give its acetamide derivatives. Further the synthesized compounds were evaluated for antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli,Pseudomonas aeruginosa and antifungal activity against, Candida albicans and Aspergillus niger. The synthesized compound were screened for their anti-inflammatory activity by carrageenan induced paw-edema method.
KEYWORDS:
In order to develop relatively small molecules as pharmacologically active molecules, a series of novel oxazolidinones having benzothiazinen and their derivatives were synthesized, and characterized by IR, 1H NMR and Mass spectral studies. Oxazolidinones were prepared from R-glycidylbutarate and Pa
Cite:
Pankaj Kumar, Jennifer Fernandes, Abhishek Kumar. Synthesis of Some Active Oxazolidinones Derivatives and Evaluation of their Antimicrobial and Anti-Inflammatory Activities. Research J. Pharm. and Tech. 7(11): Nov. 2014 Page 1292-1296.
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