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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  11

Year :  2014

Pages :   1219-1225

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and Evaluation of Losartan Potassium Sustained Release tablets



Address:   Aarti P. Nikam*, Prof. Mukesh. P. Ratnaparkhi
Marathwada Mitra Mandal’s College of Pharmacy, University of Pune, Thergaon Pune-33 India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The objective of this study was to develop the Losartan potassium sustained release tablets. This can be achieved by formulating tablets by direct compression method, by employing semi-synthetic and natural polymers like HPMCK100M, Carbopol 934 and Xanthan gum in various concentrations. The powdered blend evaluated for angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. The results obtained were satisfactory. Compressed formulations were further evaluated for thickness, friability, and hardness, swelling index and in-vitro dissolution studies. All the formulations showed good results, which were in compliance with Pharmacopoeia standards. A response surface methodology was used to select the optimized formulation wherein types of polymer and concentration of polymer were taken as independent variables and amount of drug release was taken as dependent variables. Optimization studies were carried out by using the Design Expert software version 8.0.1. The in vitro drug release followed Zero Order model and the drug release mechanism was found to be Non-Fickian type.
KEYWORDS:
Losartan potassium, Carbopol 934, Sustain release, Xanthan gum, HPMC, etc.
Cite:
Aarti P. Nikam, Mukesh. P. Ratnaparkhi. Formulation and Evaluation of Losartan Potassium Sustained Release tablets. Research J. Pharm. and Tech. 7(11): Nov. 2014 Page 1219-1225.
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