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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  10

Year :  2014

Pages :   1150-1152

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Spectrophotometric Estimation of Oxolamine citrate in Bulk and Pharmaceutical Dosage Form by Second Order Derivative Method



Address:   Rele Rajan V.*
Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai 400016.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
A simple and precise second order derivative method have been developed and validated for the estimation of oxolamine citrate in bulk and its tablet formulation. The standard and sample solutions of oxolamine citrate were prepared in distilled water. Oxolamine citrate was estimated at 257.2 nm for the second order derivative UV-spectrophotometric method. Beer’s law was obeyed in the concentration range of 1 to 14 microgram / ml with coefficient of correlation value 0.9978 for second order derivative method. The method was tested and validated for various parameters according to ICH guidelines. The precision expressed as relative standard deviation, which was as 2.0487 % for the above method. The proposed method was successfully applied for the determination of oxolamine citrate in pharmaceutical formulation. Results of the analysis were validated statistically and were found to be satisfactory. The proposed methods are simple, easy to apply, low-cost and require relatively inexpensive instruments.
KEYWORDS:
Oxolamine citrate, Second order derivative spectroscopy.
Cite:
Rele Rajan V. Spectrophotometric Estimation of Oxolamine citrate in Bulk and Pharmaceutical Dosage Form by Second Order Derivative Method. Research J. Pharm. and Tech. 7(10): Oct. 2014 Page 1150-1152.
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