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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  10

Year :  2014

Pages :   1137-1139

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Preparation and In vitro evaluation of HBsAg loaded Dextran microparticles



Address:   Mohammed M. Safhi1, S.M. Sivakumar1*, Aamena Jabeen1, N.Sukumaran2
1Department of Pharmacology and Division of Pharmaceutical Biotechnology, College of Pharmacy, Jazan University, Jazan, Kingdom of Saudi Arabia
2Sri Paramakalyani Centre for Environmental Sciences, Manonmaniam Sundaranar University, Tirunelveli, India
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Vaccines are considered as the most successful medical invention against various infectious diseases. However, there are significant barriers for improving immune response especially with recombinant vaccines. Therefore, immunopotentiators (adjuvants) are included in vaccine formulation in order to augment immune response. The present study was aimed to alter the alum type adjuvant for hepatitis B vaccine. The hepatitis B vaccine was encapsulated in dextran microparticles by emulsion cross linking technique. The formulated microparticles were characterized in terms of morphology, particle size analysis and in vitro release study. In this study we could not demonstrate the dextran microparticle system as an adjuvant for HBsAg.
KEYWORDS:
HBsAg, Dextran, microparticle system.
Cite:
Mohammed M. Safhi, S.M. Sivakumar, Aamena Jabeen, N.Sukumaran. Preparation and In vitro evaluation of HBsAg loaded Dextran microparticles. Research J. Pharm. and Tech. 7(10): Oct. 2014 Page 1137-1139.
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