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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   7

Issue No. :  10

Year :  2014

Pages :   1130-1133

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Extractive Colorimetric Method Development and Validation for the Estimation of Metaxolone in Pharmaceutical Dosage Form



Address:   Iffath Rizwana1, Dr. K. Vanitha Prakash2*, Dr. G. Krishna Mohan3
1Research Scholar, Research and Development, JNTU-K, Kakinada, A.P. India and Deccan School of Pharmacy, Hyderabad, AP, India.
2Department of Pharmaceutical Analysis, S.S.J College of Pharmacy, Gandipet, Hyderabad, A.P. India.
3Centre for Pharmaceutical Sciences, IST, JNTU Hyderabad, A.P. India.
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Two simple, precise, accurate and economical extractive visible spectrophotometric methods were developed for the determination of Metaxolone (MET) in bulk and in tablet dosage forms have been described. The method A was based on the formation of Golden Yellow color complex with Bromo cresol green, which show maximum absorbance (Lambda max) at 475nm. The method B is based on the reaction of Metanil yellow with the drug to form a highly stable Orange color complex measured at 411 nm. Mean assays of method A and B was found to be 99.60 % and 100.00 % respectively. LOD and LOQ of method A was found to be 5.22 microgram/ml and 17.41 microgram/ml respectively and for method B it was 2.77 and 9.23 microgram/ml. The results of analysis for both the methods have been validated statistically as per ICH guidelines. The proposed methods were simple, sensitive and economical for the quantitative determination of MET and were successfully employed for the estimation in pure and in tablet dosage forms.
KEYWORDS:
Metaxolone, extractive visible spectrophotometric, Bromo cresol green, Metanil yellow.
Cite:
Iffath Rizwana, K. Vanitha Prakash, G. Krishna Mohan. Extractive Colorimetric Method Development and Validation for the Estimation of Metaxolone in Pharmaceutical Dosage Form. Research J. Pharm. and Tech. 7(10): Oct. 2014 Page 1130-1133.
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