2nd International Conference on Fostering Interdisciplinary Research In Health Sciences (ICFIRHS) 2019 (01-May-2019)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  9

Year :  2013

Pages :   941-953

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Orodispersible Tablets: A review on Formulation Development Technologies and Strategies



Address:   Anjan K. Mahapatra, Ranjit P. Swain, B. Revathi, N. Nirisha, P.N. Murthy
Maharajah’s College of Pharmacy, Phool Baugh, Vizianagaram - 535 002, INDIA
Royal College of Pharmacy and Health Sciences, Berhampur, Odisha, INDIA
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Recent advances in novel drug delivery systems aimed in designing dosage forms which are convenient for manufacturing and administration, with fewer side effects, offering immediate release, with enhanced bioavailability thereby achieving better patient compliance. Orodispersible tablets (ODTs) is one such novel approach which helps to increase user acceptance by virtue of rapid disintegration, self administration without water or chewing. ODTs are solid unit dosage forms like the conventional tablets containing super disintegrants, which help them to disintegrate and/or disperse rapidly in the mouth within few seconds. In this review the authors highlighted on different criteria for selection of formulation excipients, technologies as conventional or patented and challenges to generate new strategies. Thus these formulations are particularly beneficial to the pediatric and geriatric patients affected by dysphagia. These tablets get converted into a suspension with the salivary fluid in the oral cavity thereby showing rapid onset of action with improved bioavailability. ODTs with good taste and flavor increases the acceptability of bitter drugs by patients, hence optimization of taste and flavor is a critical issue in these formulations. Better bioavailability and patient compliance along with several other benefits are the reasons for gained interest by industries for formulation development.
KEYWORDS:
Orodispersible tablets, Superdisintegrants, Techniques, Excipients and Evaluation.
Cite:
Anjan K. Mahapatra, Ranjit P. Swain, B. Revathi, N. Nirisha, P.N. Murthy. Orodispersible Tablets: A review on Formulation Development Technologies and Strategies. Research J. Pharm. and Tech. 6(9): September 2013; Page 941-953.
[View HTML]      [View PDF]



Visitor's No. :   660170