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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  8

Year :  2013

Pages :   905-907

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Extractive Spectrophotometric Method for the Determination of Metaxalone in Bulk and its Pharmaceutical Formulation



Address:   K. Sundar Babu1, P. Kareemulla1, N. V. Mahipal Reddy1, B. Mohammed Ishaq1*, N. Bharathi Natarajan2, M. Madhu1, Chakka Gopinath1
1Department of Pharmaceutical Analysis & Quality assurance, Annamacharya College of Pharmacy, Rajampet, A.P
2Chaavan College of Pharmacy, Nellore, A.P
*Corresponding Author
DOI No: Not Available

ABSTRACT:
Metaxalone, a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains and other musculoskeletal conditions a simple, sensitive, rapid and cost effective extraction spectrophotometric method was described for the assay of Metaxalone in bulk samples and pharmaceutical formulations. The method was based on the formation of chloroform soluble ion-pair complexes of Bromophenol blue with Metaxalone, formed pink colored chromogen in a phosphate buffer of pH 4 with absorbance maximum at 630nm. The developed spectrophotometric method was validated in accordance with ICH guidelines. Linearity of the method was found to be 10-50µg/ml and obeyed Beer’s law. The LOD and LOQ were found to be 0.6757 microgram/ml and2.389 microgram/ml respectively. The results of analysis for the method have been validated statistically and by recovery studies. The proposed method was simple, sensitive, accurate and suitable for quality control applications.
KEYWORDS:
Metaxalone, muscle relaxant, bromo phenol, method validation, UV- Spectroscopy
Cite:
K. Sundar Babu, P. Kareemulla, N. V. Mahipal Reddy, B. Mohammed Ishaq, N. Bharathi Natarajan, M. Madhu, Chakka Gopinath. Extractive Spectrophotometric Method for the Determination of Metaxalone in Bulk and its Pharmaceutical Formulation. Research J. Pharm. and Tech. 6(8): August 2013; Page 905-907.
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