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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  8

Year :  2013

Pages :   865-867

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Evaluation of Orally Disintegrating Tablet of Celecoxib for Juvenile Rheumatoid Arthritis



Address:   Shaikh Sohel*, M. Najmuddin, Hariprasanna R. C., Kishore V. C.
Department of Pharmaceutics, RMES’S College of Pharmacy, Gulbarga
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The aim of the study was to develop orally disintegrating tablet for Juvenile rheumatoid arthritis. Celecoxib is used to the relief of sign and symptoms of Juvenile rheumatoid arthritis. In present work an attempt has been made to prepared orally disintegrating tablet using Celecoxib by direct compression method. The tablets were prepared by using superdisintegrants such as croscarmellose sodium, crospovidone, sodium starchglycolate in different ratio and evaluated for hardness, weight variation, friability, wetting time, disintegration time, drug content and In vitro dissolution study. Drug-exipient compatibility was done by FTIR and DSC studies. Formulation CCP3 prepared dy direct compression method containing 10% crospovidone showed 92.09% of drug release in 30 minute.
KEYWORDS:
Celecoxib, Croscarmellose sodium, Sodium Starchglycolate, Crospovidone.
Cite:
Shaikh Sohel, M. Najmuddin, Hariprasanna R. C., Kishore V. C. Development and Evaluation of Orally Disintegrating Tablet of Celecoxib for Juvenile Rheumatoid Arthritis. Research J. Pharm. and Tech. 6(8): August 2013; Page 865-867.
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