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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   6

Issue No. :  7

Year :  2013

Pages :   731-735

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation, Characterization and In-vitro Evaluation of Abacavir Sulphate Loaded Microspheres



Address:   N. Chandarsekaran1*, M. Balamurugan2
1The Erode College of Pharmacy, Erode, Tamilnadu, India
2Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur Campus, No.1, Jalan Menara Gading, 56000 Kuala Lumpur, Malaysia
*Corresponding Author
DOI No: Not Available

ABSTRACT:
The aim of the present investigation was to formulate, characterize and evaluate Abacavir Sulphate (AS) loaded microspheres. Microspheres were prepared by emulsion – solvent evaporation method, using Ethyl cellulose, HPMC K4M, Eudragit RSPO and Eudragit L 100 in different combinations and proportions, in order to achieve better controlled release. The entrapment efficiency of all the formulations was found to be in the range of 79.45±7.71 to 89.79± 5.47 %. The encapsulation efficiency was also found to be dependent on nature of polymer used in the formulation. Scanning electron microscopic analysis confirmed the formation of discrete, spherical, free flowing microspheres with a size range of 25.69±10.55 micrometer to 37.93±26.39 micrometer All the formulations (F1-F8) exhibited anomalous diffusion mechanism and followed zero order kinetics. The formulation coded as F2 prepared with HPMC K4M was selected as best formulation showed 94 % of drug release at the end of 24 hours with best Physico- chemical properties. Therefore such a design can be used for the controlled delivery of AS in the form of microspheres for the treatment of HIV. Stability of the optimized formulation revealed promising results when stored under refrigeration and room temperature.
KEYWORDS:
Abacavir sulphate; microspheres; HPMC K4M; ethyl cellulose; Eudragit; release kinetics.
Cite:
N. Chandarsekaran, M. Balamurugan. Formulation, Characterization and In-vitro Evaluation of Abacavir Sulphate Loaded Microspheres. Research J. Pharm. and Tech 6(7): July 2013; Page 731-735.
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